Chronic inflammatory diseases can compromise brain health and increase dementia risk, but why and how that happens is a lingering scientific puzzle.

A multi-disciplinary team of University of Wisconsin–Madison researchers is set to launch a five-year investigation into this question.

With the support of a $3.8 million grant from the National Institutes of Health, the team plans to use a combination of brain imaging, blood-based biomarkers and animal models of Alzheimer’s disease and asthma to establish how, for whom and under what circumstances chronic systemic inflammation may contribute to or accelerate Alzheimer’s Disease and related dementia.

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